Recurring Miscarriages? The Autoimmune Connection You Shouldn’t Ignore

Expanding Autoimmune Care in Cambodia: Dr Annie Law & SingMed (Cambodia) Medical Centre

Introduction

Dr Annie Law is a Senior Consultant Rheumatologist and the Medical Director at Asia Arthritis & Rheumatology Centre (AARC) with a subspeciality interest in Systemic Lupus Erythematosus

AARC shares the vision and mission with its parent company, Beyond Medical Group, a leading healthcare organisation based in Singapore, dedicated to expanding multidisciplinary specialist services and a one-stop center for reliable and quality patient care.

Dr Law recently visited SingMed International Medical Centre in Phnom Penh, Cambodia. This familiarisation trip signifies a pivotal move towards raising awareness of autoimmune conditions and exploring collaborative patient management between AARC and SingMed. The ultimate goal is to enhance care and support for Cambodian patients.

About SingMed International Medical Centre

Established in early 2019, SingMed International Medical Centre is currently one of Phnom Penh's leading healthcare providers as well as the first Singapore-Cambodia medical centre operating in Cambodia

SingMed collaborates with Cambodian healthcare professionals and industry partners to elevate medical service standards in the country. The centre is well-versed in many medical specialities, such as rheumatology, cardiovascular care, colorectal surgery, dermatology, and family medicine.


Objectives of the Visit

Dr Law's visit to Cambodia endeavours to achieve the following outcomes:

  • Understand the healthcare needs of Cambodian patients suffering from autoimmune diseases.
  • Explore potential bilateral co-management of patients between Singapore and Cambodia.

By evaluating the current landscape, the collaboration seeks to find clinical gaps in detecting and managing autoimmune diseases, and develop suitable patient care strategies to address them effectively.

Highlights from the Visit

During her visit to SingMed, Dr Law was involved in the following:

  • Meetings with SingMed doctors and healthcare teams to discuss potential patient referrals and acquisition initiatives.
  • A filming session with Dr Buntongyi Nit, a Cambodian influencer as well as CEO and Founder of Meet Doctor, Cambodia, to raise awareness about autoimmune conditions in Cambodia. 

These initiatives highlight a deep dedication to cultivating professional collaborations that improve treatment outcomes for autoimmune conditions in Cambodia while also raising public awareness on Rheumatology.


Raising the Standard of Autoimmune Care for Cambodian Patients

The collaboration between AARC and SingMed holds promise for:

This partnership strives to build a sustainable framework for current medical exchanges, ultimately improving the standard of autoimmune care available to Cambodian patients.

Conclusion

Dr Annie Law's visit to SingMed International Medical Centre marks a key step towards elevating autoimmune healthcare in Cambodia. Through shared expertise and collaborative efforts, AARC and SingMed are poised to make marked contributions to autoimmune care in Cambodia, offering hope for enhanced health outcomes for individuals with autoimmune conditions. This will potentially enable more autoimmune patients to regain back control over their health and wellness.

Moving forward, AARC and SingMed will continue to strive to deepen their collaboration by having more medical exchanges and partnerships. 


About Dr Annie Law

Senior Consultant Rheumatologist and Medical Director at Asia Arthritis & Rheumatology Centre, part of Beyond Medical Group

Prior to setting up her own clinic, Dr Law devoted 12 years of her life to the Department of Rheumatology and Immunology at SGH, tirelessly caring for her patients. In recognition of her outstanding service to her patients, she has been duly recognised by SGH with numerous awards. Book a consultation or call for a teleconsultation with her for tailored, expert advice.


Understanding Ankylosing Spondylitis: Insights from a Rheumatologist in Singapore

What is Ankylosing Spondylitis?

Are you suffering from long-term lower back pain? If so, you could have Ankylosing spondylitis (AS) because approximately 5% of people with lower back pain may have spondyloarthritis (a group of inflammatory diseases that includes ankylosing spondylitis).

AS is a chronic inflammatory form of arthritis that primarily targets the spine. The autoimmune condition typically emerges before age 40 and can lead to symptoms like back and large joint pain, stiffness, and restricted movement. In particular, a defining symptom of AS is lower back and buttock pain that worsens with rest or inactivity, often causing pain at night during rest, early morning stiffness or pain after prolonged sitting. In the late stage of AS, the fusion of joints typically leads to a severe decrease in the flexibility and mobility of the spine. This restriction in movement can make everyday activities such as bending, twisting, and even walking difficult. 

It is important to note that the severity of AS symptoms may vary among individuals, with some experiencing periodic flare-ups and others facing chronic pain. Over time, AS can affect other parts of the spine and body, underscoring the importance of early diagnosis and proactive management.

What causes Ankylosing Spondylitis?

The exact cause of AS remains largely unknown, but it's believed to stem from a mix of genetic and environmental factors. The main genetic factor linked to AS is the HLA-B27 gene, found in nearly 90% of people with the condition. 

However, having this gene doesn't guarantee you will develop AS — only about 1-5% of people with the HLA-B27 gene do. Environmental factors like infections or other triggers can also play a role in the onset of AS.

How common is Ankylosing Spondylitis in Singapore, and who is at risk?

AS is a relatively rare autoimmune condition in Singapore, AS affects approximately 2 to 10 in 1,000 people. It typically occurs in late adolescence or early adulthood (i.e., between ages 15 and 35) and is 2-3 times more prevalent in men than women. Risk factors contributing to the condition include genetics, family history, smoking, history of previous infections and certain medical conditions (e.g., Crohn’s disease, ulcerative colitis, psoriasis and uveitis). 

How does Ankylosing Spondylitis affect daily life?

Ankylosing Spondylitis (AS) affects daily life in several ways:

What are the complications of Ankylosing Spondylitis?

Can Ankylosing Spondylitis be cured?

Unfortunately, there is no cure for AS at the moment. AS is a lifelong disease that typically progresses over time, potentially leading to significant complications if not managed properly. Thankfully, with proper management of their condition, most patients with AS can lead long, fulfilling lives and maintain a good quality of life 

How do you treat Ankylosing Spondylitis in Singapore?

When it comes to managing AS in Singapore, there are various treatment options to consider. These may include a combination of medications, physical therapy, and lifestyle changes, as recommended by rheumatologists—medical doctors who specialise in your body’s musculoskeletal and immune systems—in Singapore. For an appropriate treatment plan, consult with a specialist at a rheumatology centre in Singapore, who can provide expert advice and help you navigate treatment options.

What are the dos and don’ts for people living with Ankylosing Spondylitis?

AS can significantly impact lifestyle, but patients can maintain a good quality of life with the right approach. At Asia Arthritis & Rheumatology Centre, we advise patients with AS to adopt the following general tips to navigate daily life with AS:

Dos

  1. Attend Regular Rheumatology Clinic Check-ins in Singapore
    Stay in touch with your rheumatologist and follow her guidance. Take your meds as prescribed and keep up with recommended activities. Be transparent about your symptoms and any side effects to ensure your treatment is on track.
  2. Exercise Frequently
    Stay physically active to maintain mobility and flexibility, as well as alleviate discomfort. Avoid high-impact activities like running or heavy lifting that can exacerbate joint pain and cause further damage. Try low-impact hobbies like swimming, pilates, yoga, and tai chi, which are gentler on your joints and great for stretching the spine. But don't overlook the importance of cardio and strength training. Moreover, remember to listen to your body — do not overexert yourself.
  3. Use Assistive Devices When Necessary

If you're experiencing significant pain or difficulty with movement, don't hesitate to use assistive devices like canes or walkers. These can help reduce strain on your joints and prevent falls.

  1. Mind Your Posture
    Focus on keeping your spine straight. Some patients may want to slouch to ease the pain. However, bending the spine strains it further, which can exacerbate discomfort. Patients may also benefit from sleeping on a firm mattress with a thin pillow, and practising standing against a wall with heels, bottom, shoulders, and head touching.
  2. Eat Healthily
    An anti-inflammatory diet, rich in fruits, vegetables, whole grains, and healthy fats, can help reduce inflammation, potentially alleviating AS symptoms such as pain and stiffness. 
  1. Practice Breathing Exercises

Engaging in deep breathing exercises can help expand your chest and improve lung capacity, which is often restricted in AS patients due to chest wall stiffness.

Don’ts

  1. Avoid Smoking
    Smoking can speed up joint damage and hinder treatment effectiveness, while increasing the risk of other diseases often associated with AS, such as heart problems.
  2. Don’t Miss Out on Sleep
    Pain from AS can make it hard to sleep, which in turn can worsen your pain and leave you feeling even more exhausted. That's why it's crucial to practise good sleep habits, such as getting enough sleep, maintaining a regular sleep schedule and engaging in relaxing bedtime routines, for better rest and overall well-being.

Bear in mind that the aforementioned tips are just the rule of thumb. As the condition of each patient varies, our experienced Senior Consultant Rheumatologist will thoroughly assess your individual condition and provide specialised advice accordingly.


Advice from your Rheumatologist: How to live with Ankylosing Spondylitis

While AS can cause permanent damage and loss of motion if not managed properly, it's generally quite manageable with the right approach. Early diagnosis, appropriate treatment and lifestyle choices, as highlighted above, are key to keeping symptoms in check and enhancing quality of life. So, don't ignore backache or stiffness that lasts more than three months — seek specialised advice from a rheumatology specialist in Singapore to reduce the risk of complications.

At Asia Arthritis & Rheumatology Centre, Dr Annie Law, our Senior Consultant Rheumatologist and Medical Director,  is well-versed in AS. Book a consultation or call for a teleconsultation with her for tailored, expert advice on AS.


References

  1. National Health Service. (Updated 2023). Causes - Ankylosing spondylitis. NHS. Retrieved June 3, 2024, from https://www.nhs.uk/conditions/ankylosing-spondylitis/causes/
  2. Mayo Clinic. (December 31, 2023). Ankylosing spondylitis - Symptoms and causes. Mayo Clinic. Retrieved June 3, 2024, from https://www.mayoclinic.org/diseases-conditions/ankylosing-spondylitis/symptoms-causes/syc-20354808#causes
  3. National Institute of Arthritis and Musculoskeletal and Skin Diseases. (May 2023). Ankylosing spondylitis. NIAMS. Retrieved June 3, 2024, from https://www.niams.nih.gov/health-topics/ankylosing-spondylitis
  4. Healthdirect. (May 2023). Ankylosing spondylitis. Healthdirect Australia. Retrieved June 3, 2024, from https://www.healthdirect.gov.au/ankylosing-spondylitis
  5. Arthritis Foundation. (n.d.). 6 axSpA self-care tips. Arthritis Foundation. Retrieved June 3, 2024, from https://www.arthritis.org/diseases/more-about/6-axspa-self-care-tips
  6. Everyday Health. (Updated October 5, 2023). Ankylosing spondylitis treatment dos and don'ts. Everyday Health. Retrieved June 3, 2024, from https://www.everydayhealth.com/hs/ankylosing-spondylitis-treatment-management/treatment-dos-donts/
  7. Gracey, E., Yao, Y., Green, B., Qaiyum, Z., Baglaenko, Y., Lin, A., Anton, A., Ayearst, R., Yip, P., & Inman, R. D. (2016). Sexual Dimorphism in the Th17 Signature of Ankylosing Spondylitis. Arthritis & Rheumatology, 68(3), 679–689. https://doi.org/10.1002/art.39464
  8. Sieper, J., Braun, J., Rudwaleit, M., Boonen, A., & Zink, A. (2002). Ankylosing spondylitis: an overview. Annals of the Rheumatic Diseases, 61(Supplement 3), 8iii18. https://doi.org/10.1136/ard.61.suppl_3.iii8
  9. .Ankylosing Spondylitis Causes and Symptoms - HealthXchange. www.healthxchange.sg. https://www.healthxchange.sg/bones-joints/back-spine/ankylosing-spondylitis-causes-symptoms

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Shedding Light on Vasculitis: Understanding the ‘Invisible’ Battle Within 

Decoding Vasculitis: What is Vasculitis?

vasculitis
Vasculitis is characterised by the inflammation of the blood vessels and may result in purpura/vasculitic rash.  

Did you know that some types of illnesses are 'invisible' because their symptoms may not be readily apparent to others? Systemic vasculitis is one such example. Vasculitis refers to a group of diseases defined by the inflammation of blood vessels (arteries and veins). The autoimmune condition vasculitis can range from mild to severe, or even life-threatening.  There may be some physical manifestations, such as purpura (i.e. the presence of small bleeding points and red or purple discolourations on the skin). However, on the whole, vasculitis is considered an 'invisible' condition because there are fewer highly obvious physical symptoms relative to some other illnesses. 

Symptom Identification: What to Look Out For?

Depending on the type of vasculitis, age group, and gender, some of the possible symptoms include: 

If patients exhibit one or more of these symptoms, they should visit a rheumatologist to get an early diagnosis and start treatment. If left untreated, vasculitis can lead to severe complications as it causes inflammation of blood vessels and significantly reduces blood flow to critical organs, possibly resulting in lung and kidney inflammation, aneurysms (abnormal swelling or bulge in the blood vessel wall), and blindness.

Unfortunately, some of these symptoms and complications are not immediately visible to others, contributing to the 'invisible' nature of the disease. Individuals with vasculitis often experience muscle and joint pain, which can be uncomfortable and affect mobility. As a result, some young adults with vasculitis can look healthy but suffer from chronic pain. For instance, many need a seat on the train during their flares. This is why the the Caring SG Commuters Committee rolled out an initiative to offer specially-designed cards and lanyards to commuters with long-term, invisible medical conditions. Such societal support can greatly aid patients fighting against vasculitis.

Diagnosis: How is Vasculitis Diagnosed? 

Rheumatologists will usually advise patients who suspect that they have vasculitis to undergo one or more diagnostic tests to better understand their condition and rule out other conditions that resemble vasculitis. These tests may include:

Treatment: What Treatment Options are Available?

Currently, there is no cure for vasculitis, but proper treatment can alleviate symptoms and prevent disease progression. In general, rheumatologists prescribe immunosuppressant drugs to control inflammation and prevent complications of the condition and would advise patients to attend regular follow-up appointments.

It is important to note that there is no one-size-fits-all treatment approach for vasculitis, as treatments should be personalised based on the individual's diagnosis. Patients should consult with a rheumatologist to effectively manage their illness. 

If you are seeking a reliable and experienced rheumatologist contact Asia Arthritis & Rheumatology Centre for an appointment or call for a teleconsultation. Alongside a committed and dedicated team, our Senior Consultant Rheumatologist, Dr Annie Law, can help you effectively manage your vasculitis and cope better in your ‘invisible’ battle against the autoimmune disorder.

References

  1. Almaani, S., Fussner, L. A., Brodsky, S., Meara, A. S., & Jayne, D. (2021, April 1). Anca-associated vasculitis: An update. Journal of Clinical Medicine. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8037363/
  2. Merkel, P. A. (n.d.). Patient education: Vasculitis (Beyond the Basics). UpToDate. https://www.uptodate.com/contents/vasculitis-beyond-the-basics?csi=bc002efc-8f3a-41ce-8161-8da850926149&source=contentShare#H20
  3. Watts, R. A., Hatemi, G., Burns, J. C., & Mohammad, A. J. (2021, December 1). Global Epidemiology of Vasculitis. Nature News. https://www.nature.com/articles/s41584-021-00718-8
  4. Abdullah, A. (2021, Mar 5). Commuters with long-term medical conditions can claim card, lanyard to help get a seat on public transport. Channel NewsAsia. https://www.channelnewsasia.com/singapore/commuters-medical-conditions-card-lanyard-seat-bus-mrt-308426
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